The ability of salicylic acid to exfoliate the stratum corneum makes it a good agent for peeling. Acetylsalicylic acid is one of the most widely used drugs in the world. Sigmaaldrich 3050 spruce street saint louis mo 63103 usa telephone. Ac158180000, ac158180500, ac158185000, ac385760000 synonyms. Safety data sheet according to 29cfr19101200 and ghs rev. Jun 10, 2016 this second, completely revised edition contains the latest results of clinical and pharmacological research on acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention from cardiovascular diseases and colorectal cancer. Acetylsalicylic acid as a potential pediatric health hazard.
P indicates a commenced pmn substance r indicates a substance that is the subject of a section 6 risk management rule under tsca. Remove victim to fresh air and keep at rest in a position comfortable for breathing. Material safety data sheet otoluic acid msds section 1. Acetylsalicylic acid has both antiinflammatory and antipyretic effects. Nov 01, 2010 material safety data sheet salicylic acid msds section 1. Hoffman, setting out to create a lessirritating medicine, synthesized acetylsalicylic acid asa. Page 2 of 6 precautionarystatements p261 avoid breathing dust. Product and company identification acetylsalicylic acid synonymsgeneral names. Immediately flush eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally. Rdtoxf this sds was prepared in accordance with 29 cfr 1910. Via enrico fermi 51 24020 scanzorosciate bg italy telephone number. Acetylsalicylic acid 50782 cellulose 9004346 pennsylvania right to know acetylsalicylic acid 50782 starch 9005258 cellulose 9004346 new york city hazardous substances acetylsalicylic acid 50782 california list of hazardous substances acetylsalicylic acid 50782.
Bernauer and others published opinion on salicylic. Lascorbic acid revision date 11apr2018 component casno weight % lascorbic acid 50817 95 4. Material safety data sheet section 1 chemical product and company identification catalog numbers. Jul, 2016 various eu countries permit prescription free sales of acetylsalicylic acid in pharmacies and nonpharmacy stores. Biowaiver monograph for immediaterelease solid oral dosage. Seek medical adviceassistance if symptoms develop or persist. Acetylsalicylic acid as a potential pediatric health. Acetonitrile safety data sheet according to federal register vol. In the uk a maximum of 16 tablets of acetylsalicylic acid 325 mg is allowed to sell in nonpharmacies. This document communicates information relating to test and assay use only and may not be applicable for any unauthorized use. Acetylsalicylic acid definition of acetylsalicylic acid by. Novacyl safety data sheet for rhodine 3020, version 11, 20 february 2014. Acetylsalicylic acid is a weak acid and the pka value has variously been reported as 3.
Benzoic acid revision date 23jan2015 evaporation rate not applicable flammability solid,gas no information available flammability or explosive limits upper no data available lower no data available vapor pressure 1. Hazardous waste disposal guidelines purdue university. Skin contact wash off immediately with plenty of water for at least 15 minutes. Material safety data sheet acetylsalicylic acid 415 huguenot street new rochelle, ny 10801 phone. Acetylsalicylic acid msds free download as pdf file. Acetic acid safety data sheet according to federal register vol. As5055h, as5055e, as5055i, as5055j, as5055k, as5055m product identity. Study of degradation kinetic of acetylsalicylic acid the degradation kinetic of acetylsalicylic acid was followed by the deacetylation reaction and, consequently, by the salicylic acid formation. The ancient sumerians and egyptians, as well as hippocrates, celsus, pliny the elder, dioscorid. Development of a new analytical method for determination. A freshly prepared average preparation time of 25 minutes solution of acetylsalicylic acid 0. Ac158180000, ac158180025, ac158185000, ac385760000 synonyms. N indicates a polymeric substance containing no free radical initiator in its inventory name but is considered to cover the designated polymer made with any free radical initiator regardless of the amount used. Children under the age of 12, unless they have a congenital heart defect requiring anticlotting drugs, shouldnt use aspirin, and it should never be used in kids with stomach flu, respiratory illnesses or chicken pox.
Acetylsalicylic acid cas 50782 sdssafety data sheet. Acetylsalicylic acid 50782 100 section 4 first aid measures emergency and first aid procedures inhalation. First aid measures always seek professional medical attention after first aid measures are provided. This material is considered hazardous by the osha hazard. Hydrolysis of methyl salicylate and synthesis of acetylsalicylic acid. The official united states pharmacopoeia usp suggests. Aspirin should not be given to children who have viral infections, because this has been associated with the subsequent development of reyes syndrome. This product contains acetylsalicylic acid aspirin, a. See salicylate for adverse reactions and poisoning.
Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. Benzoic acids salt sodium benzoate is commonly used as a ph adjustor and. Its ancestry the salicylates, including salicin and salicylic acid, are found in the bark and leaves of the willow and poplar trees. A deficient method of preparation of aspirin could produce acetylsalicylic acid impurified with free salicylic acid, which presents adverse health effects. Hazardous in case of skin contact irritant, of eye contact irritant.
A very simple method of detection of the free salicylic acid could be based on the different. In case of contact with eyes, rinse immediately with. Pdf,epub,kindle download acetylsalicylic acid eboook for. Also known as aspirin, acetylsalicylic acid asa is a commonly used drug for the treatment of pain and fever due to various causes. Fisher scientific 1 reagent lane fairlawn, nj 07410 for information, call. Fisher scientific one reagent lane fair lawn, nj 07410.
Laboratory chemical solvent chemical raw material pesticide. Acetylsalicylic acid aspirin can be found on the following state right to know lists. Acetylsalicylic acid msds aspirin personal protective. Concentrated sulfuric acid will react with many organic materials and may cause fire due to the. Acetylsalicylic acid aspirin material safety data sheet. Furthermore, esters of asa alkylor aralkylsubstituted asa such as methyl, ethyl, al. When released into air, this material is expected to have a halflife between 10 and 30 days. California, new jersey, florida, pennsylvania, minnesota, massachusetts. The following statements isare made in order to comply with the california safe drinking water act. Acidbase determination of acetylsalicylic acid in tablets. Firstaid measures eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. First, the free carboxylic acid group will be produced when we hydrolyze. Material safety data sheet acetylsalicylic acid msds section 1.
In sweden acetylsalicylic acid 500 mg may be sold in a maximum package size of 20 tablets or effervescent tablets in a nonpharmacy. Central drug house p ltd 728 vardaan house new delhi 12 india. These include aluminum, calcium, and sodium salts as well as lysine salts, the latter of which are intended for intravenous administration. It cannot be excreted from the body by ventilation but must be excreted by organs other than the lungs, e.
Pdf opinion on salicylic acid cas 69727 submission i. National library of medicine hazardous substances data bank online. Salicylic acid has been used to treat various skin disorders for more than 2,000 years. Acetylsalicylic acid definition of acetylsalicylic acid. For more information on benzoic acid and other hazardous.
It is also soluble in ethanol at 50 mgml and will dissolve in solutions of alkali hydroxides and carbonates with decomposition. Aqueous solutions of acetylsalicylic acid are most stable at ph 2. Acetylsalicylic acid is usually given orally as the free acid, but various salts also exist. For more information, consult the safety data sheet or contact your wards. Aspirin is a salicylate, and irreversible cox1 and cox2 inhibitor, used as an analgesic to relieve minor aches. Pdf,epub,kindle download 2017 colorful stained glass monthly planner. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction mi. Show this safety data sheet to the doctor in attendance. This agent exhibits analgesic, antipyretic, and anticoagulant properties. Classification of the substance or mixture reg ce 12722008.
The concurrent use of aspirin and nsaids also increase the risk of serious gastrointestinal adverse effects see section 4. Safety data sheet malic acid revision 7 01122014 en cas n 6915157 ec n 2300228 pictograms. Material safety data sheet west liberty university. Salicylic acid acetate, aspirin, 2acetyloxybenzoic acid. An acid, such as lactic acid or sulfuric acid, that accumulates in the body as a result of digestion, disease, or metabolism. Acid base determination of acetylsalicylic acid in tablets aspirin is the trade name of drugs containing organic chemical compound named acetylsalicylic acid. It is widely used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an antiinflammatory medication. Material safety data sheet laspartic acid msds section 1. Nov 01, 2010 material safety data sheet acetylsalicylic acid msds section 1. Aspirin is an orally administered nonsteroidal antiinflammatory agent.
Biowaiver monograph for immediaterelease solid oral. Acetylsalicylic acid is slightly soluble in water, with a limit of solubility reported as approximately 3 mgml at 25 deg c. When released into water, this material is expected to readily biodegrade. Chemical product and company identification product name. He a lt h 2 1 1 fire 2 0 re a c t iv it y 0 p e rs o n a l e p ro t e c t io n material safety data sheet acetylsalicylic acid msds section 1. Download free acetylsalicylic acid ebook for kindle tablet ipad android download link download acetylsalicylic acid bookebook pdf epub kindle online for free 20161103. Ace acetic acid nitrile cyanomethane ethane nitrile ethyl nitrile methane carbonitrile methyl cyanide. One reagent lane fair lawn, nj 07410 for information in north america, call. Aspirin hc9h7o4 or c9h8o4 cid 2244 structure, chemical names, physical and. Aqueous solutions of acetylsalicylic acid are most stable at ph 2 3, but to assure full. Jan 24, 2021 acetylsalicylic acid, or aspirin, is an antipyretic with feverreducing properties. Development of a new analytical method for determination of. Salicylic acid as is a precursor in aas synthesis and is also produced during its degradation.
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